Usually, practice Reduce penis sensitivity perfect. Persistent Reduce penis sensitivity of the penis head and foreskin can result in scarring, which can cause a tightening of the foreskin phimosis and a narrowing of the urethra tube that drains urine from the bladder. Penile Cancer Cancer of the Penis Cancer of the penis affects the skin and tissues of the penis. An individual may experience this numbness in the lower body and groin area. Soaps and other hygiene products are more likely to irritate the sensitive skin on and around the penis.